Patient
About CHIME uitklapper, klik om te openen
There are around 55 million people worldwide living with dementia, including Alzheimer's disease. Dementia is caused by different brain diseases and is still not curable. Importantly, the changes in the brain that lead to dementia often begin many years, even decades, before symptoms appear.
The CHIME consortium aims to better understand these early changes. By identifying them sooner, we hope to improve diagnosis and support the development of new treatments. Our research focuses on three important processes that keep the brain healthy: blood flow, brain energy use, and waste removal.
The brain depends on a healthy blood supply to deliver oxygen and nutrients. We study how well blood moves through the small vessels in the brain, how these vessels respond to changes, and how well the brain’s protective barrier is functioning. In addition, the brain needs a constant supply of energy to work properly. In dementia, the way the brain produces and uses energy can change, and we are developing new MRI methods to measure these processes in more detail and over time. Finally, the brain has a natural system to remove waste products. If this system does not work well, harmful substances can build up and contribute to disease. We aim to better understand and measure how effectively the brain clears these substances.
Participate in research uitklapper, klik om te openen
Research is essential to improve care for people with dementia, including Alzheimer's disease, by helping us find early signs of the disease and develop treatments that can slow, prevent, or eventually cure it. To make this research possible, we rely on the participation of volunteers. Both healthy individuals and people with (early signs of) neurological conditions are essential to help us better understand how the brain works and how it changes over time.
There are currently no ongoing studies. New studies will be launched in the future, so we encourage you to check this website for updates and opportunities to participate.